Safety & Toxicity

SAFETY & TOXICITY

Safety and Toxicity Data

HOCl contains no alcohol, is non-flammable, has no COSHH implications and causes no harm to the environment. At low concentrations it offers a skin neutral pH and is non-sensitising to skin or eyes. At higher concentrations it can be used in industrial applications without the use of PPE or having to be transported as a hazardous substance.



 

Chemicals Hazard Information & Packaging (CHIP)




 


Symbol

Risk

Risk phrase

HOCl 4000

Irritant

Eye irritant

HOCl 2000

N/A

None

HOCl 1000

N/A

None

HOCl  800

N/A

None

HOCl  700

N/A

None

HOCl  600

N/A

None

HOCl  500

N/A

None

HOCl  250

N/A

None



Toxicology / Mutagenicity


Full independent toxicity human risk assessment conducted on 2,000ppm HOCl concluded that HOCl at its stated formulation (<1% calcium hypochlorite in water, 2000 ppm afc), is neither a skin nor eye irritant and presents no risk to human health if used as intended. Full bacterial reverse mutagenicity testing has proven HOCl 2000 to be completely non-mutagenic. This was conducted by exposing specially selected strains of Salmonella typhimurium and E coli to HOCl 2000 and incubating both bacteria and test substance in the absence and presence of a supplemented homogenate fraction (S9 mix). The substance was then evaluated for base change mutagens: S. typhimurium TA1535 and TA100, and E. coli WP2 uvrA (pKM101) and frameshift mutagens: S. typhimurium TA1537 and TA98. All testing was conducted in compliance with the UK Good Laboratory Practice Regulations (Statutory Instrument No. 3106), the OECD Principals of Good Laboratory Practice ENV/MC/CHEM (98) 17 and EC Commission Directive 2004/10/EC.


The mutagenicity study was conducted in compliance with: OECD Guidelines for the Testing of Chemicals (1997). Genetic Toxicology: Bacterial Reverse Mutation Test, Guideline 471. EC Commission Regulation No. 440/2008. Method B.13/14: Mutagenicity - Reverse mutation test using bacteria. OJ L 142/248. US EPA Health Effects Test Guidelines (1998). OPPTS 870.5100 Bacterial reverse mutation test. EPA 712-C-98-247.


 Kenneth May BSc, Cbiol, MSB. 06/2010



Salvox Safety

Weight of Evidence Toxicity Report

“In conclusion, review of the data available in the public domain indicates that Salvox (HOCl) 2000 at its stated formulation is likely to be of low toxicity and unlikely to be a skin or eye irritant or a skin sensitiser. This information is considered to be sufficiently accurate for human risk assessment and to conclude that Salvox 2000 presents no risk to human health if used as intended.”

D.G.Coleman BSc Hons. 5/2011, Cambridge

Patrons: Professor Carlton Evans, Dr Sumona Datta, Sir Richard Stilgoe & Dr Hugh Martin

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